I also post my solution in ESRI community for more people to use.
https://community.esri.com/t5/arcgis-pro-questions/label-expression-set-font-size/td-p/182261
Function FindLabel ( [STREET_NUMBER], [notes] ) If IsNull([notes]) Then FindLabel = [STREET_NUMBER] Else FindLabel = [STREET_NUMBER] + vbcrlf + "<FNT size='2'>" + [notes] + "</FNT>" End If End Function