I also post my solution in ESRI community for more people to use.

https://community.esri.com/t5/arcgis-pro-questions/label-expression-set-font-size/td-p/182261

 

 

 

 

 

Function FindLabel ( [STREET_NUMBER], [notes] )
If IsNull([notes]) Then
  FindLabel = [STREET_NUMBER]
Else
 FindLabel = [STREET_NUMBER] +   vbcrlf + "<FNT size='2'>" + [notes] + "</FNT>"
End If

End Function
by

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